Understanding Insulin Action

Author: J. Espinal
Publisher: Springer Science & Business Media
ISBN: 1461314755
Size: 21.79 MB
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Every year between three and four hundred papers are published on the topic of insulin action. This extraordinary publication rate prevents any author from includ ing an exhaustive bibliography in any review or book. Perhaps due to this there is no single text that attempts to cover the effects and the mechanism of action of insulin. This book is such an attempt. I intend to present a review of the physiological effects of insulin, the pathology of defects in the action of insulin, and the current views on the mechanism of action of this hormone. I make no apology for the fact that the bibliography will not be extensive and that the amount of experimental detail and data discussed will be kept to a relevant minimum. This book is not intended for the expert in the field, but for the second- or third-year undergraduate and graduate student of medicine, biochemistry, physiology or related disciplines, and will be valuable as a reference source for research workers. The book is presented as a guide, a summary of the ideas and facts; it will present a reader with a foretaste of a fascinating and ever-changing field. I have attempted to be up-to-date with published research work. Any significant contributions to the field not included in the first draft have been added as footnotes. I assume a basic knowledge of the metabolic pathways of carbohydrates, fats and proteins.

The Lung In Its Environment

Author: G. Bonsignore
Publisher: Springer Science & Business Media
ISBN: 1468439715
Size: 19.69 MB
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This volume documents the proceedings of a symposium on "Lung in its Environment" held at the Ettore Majorana 'Center for Scientific Culture, in Erice, Sicily, between 16th June and 21st June 1980. This was attended by about 200 participants drawn from Europe as a whole, but the majority were from Southern Europe. The discussion was recorded either in English or Italian and the tapes were reduced to a verbatim typescript by the Ente Nazionale Interpreti Congresso. The verbatim typescript has been edited using a few guiding principles as follows:- 1. Titles and honorifics have been eliminated unless the statement is addressed to a specific person. 2. The style of the speakers in the discussion has been preserved as far as possible and not reduced to a strictly grammatical format. 3. Where references to illustrations (e.g., on the blackboard) are made, the comments have been left unaltered and many are understandable. Removing them detracted from the sense. 4. The air of informality in the proceedings has been preserved so far as possible. 5. The responsibility for the discussion rests solely with the editors, and no contributor has had the opportunity of correcting what he said. 6. No manuscript was received from two participants, but the discussion of their presentations has been included since it contains some points of substance. 7.

Water Science Reviews

Author: Felix Franks
Publisher: Cambridge University Press
ISBN: 9780521099028
Size: 20.96 MB
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Interest in water in all its forms and in all its properties will continue to grow for a long time to come. It will spread over a large number of disciplines and technologies. Research into water in all its aspects has become so diverse that even those with a direct interest find it impossible to keep up with the original literature beyond a very limited range. On the other hand, scientists want to keep in touch with a wide spectrum of basic and applied research on water and the role played by aqueous solvents in physical, chemical, biological, technological and environmental processes. Water Science Reviews contains three or four critical state-of-the-art reviews of the type previously published in the seven volume work Water - A Comprehensive Treatise. Some reviews will update previously published topics, while others will feature areas of Water Sciences that have never yet been reviewed. A common focus will be the central position adopted by water in the systems and processes described. A selective bibliography will direct interested readers to the original source literature.

Molecular Gastronomy

Author: Hervé This
Publisher: Columbia University Press
ISBN: 9780231133128
Size: 44.67 MB
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Bringing the instruments and experimental techniques of the laboratory into the kitchen, Herve This uses recent research in the chemistry, physics, and biology of food to challenge traditional ideas about cooking and eating. What he discovers will entertain, instruct, and intrigue cooks, gourmets, and scientists alike. Molecular Gastronomy, This's first work to appear in English, is filled with practical tips, provocative suggestions, and penetrating insights. This begins by reexamining and debunking a variety of time-honored rules and dictums about cooking and presents new and improved ways of preparing a variety of dishes from quiches and quenelles to steak and hard-boiled eggs. He goes on to discuss the physiology of flavor and explores how the brain perceives tastes, how chewing affects food, and how the tongue reacts to various stimuli. Examining the molecular properties of bread, ham, foie gras, and champagne, the book analyzes what happens as they are baked, cured, cooked, and chilled.

Saproxylic Insects

Author: Michael D. Ulyshen
Publisher: Springer
ISBN: 331975937X
Size: 34.13 MB
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This volume offers extensive information on insect life in dying and dead wood. Written and reviewed by leading experts from around the world, the twenty-five chapters included here provide the most global coverage possible and specifically address less-studied taxa and topics. An overarching goal of this work is to unite literature that has become fragmented along taxonomic and geographic lines. A particular effort was made to recognize the dominant roles that social insects (e.g., termites, ants and passalid beetles) play in saproxylic assemblages in many parts of the world without overlooking the non-social members of these communities. The book is divided into four parts: · Part I “Diversity” includes chapters addressing the major orders of saproxylic insects (Coleoptera, Diptera, Hymenoptera, Hemiptera, Lepidoptera and Blattodea), broadly organized in decreasing order of estimated global saproxylic diversity. In addition to order-level treatments, some chapters in this part discuss groups of particular interest, including pollinators, hymenopteran parasitoids, ants, stag and passalid beetles, and wood-feeding termites. · Part II “Ecology” discusses insect-fungal and insect-insect interactions, nutritional ecology, dispersal, seasonality, and vertical stratification. · Part III “Conservation” focuses on the importance of primary forests for saproxylic insects, offers recommendations for conserving these organisms in managed forests, discusses the relationships between saproxylic insects and fire, and addresses the value of tree hollows and highly-decomposed wood for saproxylic insects. Utilization of non-native wood by saproxylic insects and the suitability of urban environments for these organisms are also covered. · Lastly, Part IV “Methodological Advancements” highlights molecular tools for assessing saproxylic diversity. The book offers an accessible and insightful resource for natural historians of all kinds and will especially appeal to entomologists, ecologists, conservationists and foresters.

Pediatric Infectious Diseases Revisited

Author: Stefan Wirth
Publisher: Springer Science & Business Media
ISBN: 3764380993
Size: 63.27 MB
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Starting with historical, epidemiological and sociocultural issues, this book presents clinical and molecular biological aspects of pediatric infectious diseases. The text offers new insights into the pathogenesis of infection, and updates on diagnostics, prevention and treatment of pediatric viral, fungal and bacterial diseases, as well as emerging new pathogens. The book will interest an interdisciplinary audience of clinicians and non-clinicians: pediatricians, infectious disease researchers, virologists, microbiologists and more.

Adult Stem Cells In Aging Diseases And Cancer

Author: K.L. Rudolph
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027324
Size: 27.88 MB
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The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Neurobiology

Author: Franco Conti
Publisher: Springer Science & Business Media
ISBN: 1461558999
Size: 55.62 MB
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Understanding how the brain works is undoubtedly the greatest challenge for human intelligence and one of the most ambitious goals of contemporary science. We are certainly far from this goal, but significant advancements in several fields of Neuroscience and Neurobiology are being obtained at an increasing pace. The NATO ASI School in Neurobiology, held in Erice May 2-12,1995, as the 23rd Course of the International School of Biophysics, provided an update on three basic topics: Biophysics and Molecular Biology ofIon Channels, Sensory Transduction, and Higher Order Functions. Current knowledge on these subjects was covered by formal lectures and critical discussions between lecturers and participants. This book collects original contributions from those scientists who attended the School. Many students presented their results in poster sessions, steering lively informal discussions. A selection of these contributions is also included. A major portion of the program of the School was devoted to a general overview of current trends of thought and experimental approaches in neurobiology, emphasising the importance of understanding molecular aspects of the elementary events underlying sensory transduction and processing in the nervous system, without indulging however in a pure reductionistic view of such complex phenomena. Recent studies of molecular biology and the electrophysiology of heterologously expressed ionic channels, have shed new light on the molecular mechanisms underlying ionic permeation of excitable membranes and its regulation by physical and chemical parameters.

The Cancer Degradome

Author: Dylan Edwards
Publisher: Springer Science & Business Media
ISBN: 0387690573
Size: 25.64 MB
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This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Handbook Of Neurochemistry

Author: Abel Lajtha
Publisher: Springer Science & Business Media
ISBN: 1461571723
Size: 15.42 MB
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Anyone who has any contact with mental patients, old or young, or their families, or just visits a mental hospital or school for the retarded, is aware of the tremendous suffering caused by malfunctioning of the brain. The func tion of no other organ is so crucial for our everyday life, our proper func tioning, indeed our happiness, and no other illness causes as much anguish to patients or their families as mental illness. It is surprising and sad, therefore, how little effort has been devoted to research in this area; more so because such research is the only hope to ameliorate this suffering, or, to speak in the language of politics or economics, to decrease the enormous sums that we spend on trying to help our patients, with what is must generally be agreed are the most primitive and inadequate methods of treatment. Clearly, since functions of the brain are vital not only in illness, but in health, pathology is not the only area of concern to neurochemists, but it is an area that urgently needs neurochemical contributions. Progress in this field has been slower than in other areas of neurochemistry, and it seems that solutions in this field are very elusive. The reason for this is that the experimental approach is especially difficult in conditions specific for humans, or specific for complex behavior.