Organic Synthesis

Author: Stuart Warren
Publisher: John Wiley & Sons
ISBN: 1119965535
Size: 13.24 MB
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One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

Workbook For Organic Synthesis The Disconnection Approach

Author: Stuart Warren
Publisher: John Wiley & Sons
ISBN: 1119965551
Size: 51.18 MB
Format: PDF, ePub, Docs
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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

Organic Synthesis Workbook

Author: Stuart Warren
Publisher: John Wiley & Sons
ISBN: 9780471900825
Size: 46.88 MB
Format: PDF
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A workbook providing additional examples, problems, and solutions for use with Warren′s Organic Synthesis: The Disconnection Approach. Exercises correspond to chapters in the main text. Problems of special ease or difficulty are labeled for optional use. Workbook includes a formula index of all target molecules contained in the text and workbook.

Organic Synthesis

Author: Paul Wyatt
Publisher: John Wiley & Sons
ISBN: 1118681444
Size: 59.65 MB
Format: PDF, Mobi
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Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Designing Organic Syntheses

Author: Stuart Warren
Publisher: John Wiley & Sons
ISBN: 9780471996125
Size: 54.74 MB
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"This book confronts the student with the problem of synthesizing molecules given nothing but their structure. The synthon approach is used: disconnections breaking the molecule into useable fragments (synthons) are introduced to the student, who then teaches himself how to use them by solving a series of problems of steadily increasing difficulty"--Cover.

Introduction To Strategies For Organic Synthesis

Author: Laurie S. Starkey
Publisher: John Wiley & Sons
ISBN: 1119347238
Size: 79.37 MB
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Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.

Hybrid Retrosynthesis

Author: Michael B. Smith
Publisher: Elsevier
ISBN: 0124115276
Size: 77.59 MB
Format: PDF, ePub, Docs
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Designed to supplement existing organic textbooks, Hybrid Retrosynthesis presents a relatively simple approach to solving synthesis problems, using a small library of basic reactions along with the computer searching capabilities of Reaxys and SciFinder. This clear, concise guide reviews the essential skills needed for organic synthesis and retrosynthesis, expanding reader knowledge of the foundational principles of these techniques, whilst supporting their use via practical methodologies. Perfect for both graduate and post-graduate students, Hybrid Retrosynthesis provides new applied skills and tools to help during their organic synthesis courses and future careers, whilst simultaneously acting as useful resource for those setting tutorial and group problems, and as a helpful go-to guide for organic chemists involved in either industry or academia. Ideal revision and hands on learning guide for organic synthesis Clearly explains the principles and practice of retrosynthesis, which is often not covered in other books Encourages readers to practice their synthetic knowledge supported by real life examples