Nmr Of Biomolecules

Author: Ivano Bertini
Publisher: John Wiley & Sons
ISBN: 3527328505
Size: 46.56 MB
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NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

Nmr Of Proteins And Small Biomolecules

Author: Guang Zhu
Publisher: Springer Science & Business Media
ISBN: 3642289169
Size: 74.68 MB
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Application of NMR and Molecular Docking in Structure-Based Drug Discovery, by Jaime L. Stark and Robert Powers NMR as a Unique Tool in Assessment and Complex Determination of Weak Protein-Protein Interactions, by Olga Vinogradova and Jun Qin The Use of Residual Dipolar Coupling in Studying Proteins by NMR, by Kang Chen und Nico Tjandra NMR Studies of Metalloproteins, by Hongyan Li and Hongzhe Sun Recent Developments in 15N NMR Relaxation Studies that Probe Protein Backbone Dynamics, by Rieko Ishima Contemporary Methods in Structure Determination of Membrane Proteins by Solution NMR, by Tabussom Qureshi and Natalie K. Goto Protein Structure Determination by Solid-State NMR, by Xin Zhao Dynamic Nuclear Polarization: New Methodology and Applications, by Kong Hung Sze, Qinglin Wu, Ho Sum Tse and Guang Zhu

Nmr For Chemists And Biologists

Author: Rodrigo J Carbajo
Publisher: Springer Science & Business Media
ISBN: 9400769768
Size: 36.60 MB
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This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the development experienced by NMR in recent times. Many of the books currently available on NMR deal with the theoretical basis and some of its main applications, but they generally demand a strong background in Physics and Mathematics for a full understanding. This book is aimed to a wide scientific audience, trying to introduce NMR by making all possible effort to remove, without losing any formality and rigor, most of the theoretical jargon that is present in other NMR books. Furthermore, illustrations are provided that show all the basic concepts using a naive vector formalism, or using a simplified approach to the particular NMR-technique described. The intention has been to show simply the foundations and main concepts of NMR, rather than seeking thorough mathematical expressions.

Bionmr In Drug Research

Author: Oliver Zerbe
Publisher: John Wiley & Sons
ISBN: 3527605428
Size: 30.16 MB
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The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited by a former coworker of Wuthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.

High Magnetic Fields

Author: Claude Berthier
Publisher: Springer
ISBN: 354045649X
Size: 48.85 MB
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This book is addressed to all scientists interested in the use of high magnetic ?elds and in the use of high-?eld facilities around the world. In particular it will help young scientists and newcomers to the topic to gain a better understanding in areas such as condensed matter physics, in which the magnetic ?eld plays a key role either as a parameter controlling the Hamiltonian, or as an experimental tool to probe the underlying mechanism. This concerns mostly strongly correlated and (or) low dimensional systems. Rather than covering all these subjects in detail, the philosophy here is to give essential physical concepts in some of the most active ?elds, which have been quickly growing in the last ten to twenty years. Besides its role as a physical parameter in condensed matter physics, a large magnetic ?eld is essential to Electron Paramagentic Resonance (EPR) and Nuclear Magnetic Resonance (NMR) spectroscopies. The state of art of high resolution NMRin liquids and solids and high frequency EPRapplied to ?elds like chemistry and biology are also reviewed in this volume. The ?rst series of chapters is devoted to the integer and the Fractional Qu- tum Hall E?ects (FQHE) in two-dimensional electron systems. C. Glattli brushes an historical background and a comprehensive review of transport phenomena in these systems, including recent developments on the mesoscopic electronic transport at the edges of quantum Hall samples, chiral Luttinger liquids and fractional excitations. R.

Drug Discovery And Design

Author: John Matsoukas
Publisher: IOS Press
ISBN: 9784274905223
Size: 56.14 MB
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This work covers review articles and research articles related to the "Bioactive Drugs in Drug Discovery Design". It covers the synthesis and properties of bioactive molecules and enzymes, the role of membranes in drug activity and formulation.

Computational Methods To Study The Structure And Dynamics Of Biomolecules And Biomolecular Processes

Author: Adam Liwo
Publisher: Springer Science & Business Media
ISBN: 3642285546
Size: 58.59 MB
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Since the second half of the 20th century machine computations have played a critical role in science and engineering. Computer-based techniques have become especially important in molecular biology, since they often represent the only viable way to gain insights into the behavior of a biological system as a whole. The complexity of biological systems, which usually needs to be analyzed on different time- and size-scales and with different levels of accuracy, requires the application of different approaches, ranging from comparative analysis of sequences and structural databases, to the analysis of networks of interdependence between cell components and processes, through coarse-grained modeling to atomically detailed simulations, and finally to molecular quantum mechanics. This book provides a comprehensive overview of modern computer-based techniques for computing the structure, properties and dynamics of biomolecules and biomolecular processes. The twenty-two chapters, written by scientists from all over the world, address the theory and practice of computer simulation techniques in the study of biological phenomena. The chapters are grouped into four thematic sections dealing with the following topics: the methodology of molecular simulations; applications of molecular simulations; bioinformatics methods and use of experimental information in molecular simulations; and selected applications of molecular quantum mechanics. The book includes an introductory chapter written by Harold A. Scheraga, one of the true pioneers in simulation studies of biomacromolecules.

Annual Reports On Nmr Spectroscopy

Author: Graham A. Webb
Publisher: Academic Press
ISBN: 0124051839
Size: 32.80 MB
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Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy

Nmr

Author: R. Born
Publisher: Springer Verlag
ISBN: 9783540620105
Size: 41.33 MB
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