Muscle Metabolism

Author: Juleen R Zierath
Publisher: CRC Press
ISBN: 9780203166420
Size: 66.75 MB
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Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention have recently been derived from work with such animal models. This book presents the state-of-the-art knowledge in the field of diabetes research directed at understanding the mechanisms governing the development of skeletal muscle insulin resistance. Muscle Metabolism will be of significant interest for those researching diabetes at an experimental level in both academia and the pharmaceutical industry. In addition, it will also be of interest to researchers in the fields of obesity, metabolism, endocrinology and molecular biology.

Animal Models Of Diabetes Second Edition

Author: Eleazar Shafrir
Publisher: CRC Press
ISBN: 9781420009453
Size: 29.86 MB
Format: PDF, ePub
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As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Peroxisome Proliferator Activated Receptors From Basic Science To Clinical Applications

Author: J.-C. Fruchart
Publisher: Springer Science & Business Media
ISBN: 1461511712
Size: 44.89 MB
Format: PDF, Kindle
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Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. As a consequence, our knowledge of the role of these receptors in physiology and pathology continues to grow at a fast pace and PPARs have become an interesting target for the treatment of many pathological conditions, including diabetes and atherosclerosis. This volume provides an authoritative view of the current clinical and scientific developments within this evolving area of study.

Animal Models In Diabetes

Author: Eleazar Shafrir
Publisher: CRC Press
ISBN: 020330473X
Size: 78.57 MB
Format: PDF, ePub, Mobi
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Animal Models of Diabetes: A Primer introduces characteristics of the most commonly used animal species with various diabetic syndromes which have been developed and extensively investigated during the last few decades. It includes animal models that are readily available, well described and proven to be of value in the research of both types of diabetes. Extensively referenced, this book will be of value to new and established investigators, graduate students and pharmaceutical scientists working on the development of antidiabetic and preventative modalities in various areas of diabetes and its complications.

Chronic Complications In Diabetes

Author: Anders A F Sima
Publisher: CRC Press
ISBN: 1482298236
Size: 12.17 MB
Format: PDF, Kindle
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Individual volumes in the series Frontiers in Animal Diabetes Research provide basic researchers as well as clinical investigators with in-depth coverage of basic experimental diabetes research. Each volume will be topic oriented with timely and liberally referenced reviews. The series will provide a valuable reference source for basic researchers as well as clinical investigators, graduate students and research fellows in the areas of diabetology, endocrinology, physiology, and pharmacology. Major advances have been made in diabetes research, partly as a result of experimentation in animal models. Experimental animal research has contributed significantly to the understanding of the aetiology of this disease and its dreaded complications. In particular the areas of immunology, insulin signal transduction, and the pathogenetic mechanisms involved in the chronic complications have become clearer. Various animal models used in diabetes research are reviewed, together with the diverse but often interrelated mechanism in the complication of diabetes. The functional and structural consequences in the various target organs are also discussed. Students, trainees, fellows, as well as clinicians and investigators interested in diabetes and its complications will find this new book series a valuable reference source.

Insulin Resistance And Insulin Resistance Syndrome

Author: Barbara Hansen
Publisher: CRC Press
ISBN: 0203217411
Size: 53.29 MB
Format: PDF, ePub
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Type II diabetes has developed into a global epidemic, with nearly 20 type II patients for every type I individual. Preceding the onset of type II diabetes is a prolonged episode of insulin resistance featuring a host of detrimental symptoms. This period comprises a disease referred to as Insulin Resistance Syndrome or Metabolic Syndrome. Insulin Resistance and Insulin Resistance Syndrome deals with the cellular and whole body pathogenic mechanisms and phenotypic expressions in various models of insulin resistance. Leaders in the field provide their perspectives on the mechanisms of insulin resistance, as observed in various animal models. While the exact mechanism underlying resistance to insulin is unknown, the authors review many of the significant factors. A series of chapters on Metabolic Syndrome discusses its possible insulin resistance-associated pathophysiology with obesity, cardiovascular disease, hypertension, glucose intolerance, and abnormalities in whole body metabolism. Presenting essential knowledge in the field of insulin resistance, this book will benefit clinicians, pharmaceutical scientists, and researchers involved in endocrinology, biochemistry and metabolism in diabetes.

Frontiers In Clinical Drug Research Diabetes And Obesity

Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 1681081857
Size: 36.74 MB
Format: PDF, Mobi
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Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The second volume of this series features 7 reviews presenting updates on hormones and several classes of drugs: -Osteocalcin action in glucose metabolism -Sodium-glucose co-transporter 2 (SGLT2) inhibitors -Glucagon-like peptide-1 (GLP-1) mimetics -Dipeptidyl peptidase 4 (DPP-4) inhibitors -New drugs in clinical trial and commercial phases

Endocrinology And Metabolism

Author: Paul W. Ladenson, M.D.
Publisher: Physician's Desk Reference (PDR)
ISBN: 9781563634673
Size: 20.76 MB
Format: PDF
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Clear and concise Internet navigational directories designed to lead physicians directly to websites that have been reviewed by peer leaders and professionals in various medical specialties. Each guide focuses on a single specialty and reviews over 1,600 related websites. Unlike search engines, eMedguides list only authoritative sites that offer useful professional content. eMedguide reviews are posted and continuously updated at www.emedguides.com, where you can easily click directly to any website reviewed.