Author: Joseph Hill
Publisher: Academic Press
ISBN: 012381510X
Size: 79.86 MB
Format: PDF, Kindle
View: 4818

Autophagy And Cardiometabolic Diseases

Author: Jun Ren
Publisher: Academic Press
ISBN: 0128054425
Size: 38.20 MB
Format: PDF, Docs
View: 758
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Dietary Fiber For The Prevention Of Cardiovascular Disease

Author: Rodney A. Samaan
Publisher: Academic Press
ISBN: 0128052759
Size: 17.80 MB
Format: PDF, ePub
View: 3108
Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber’s Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health compiles the most up-to-date research discoveries to provide a timely and scientific rationale for the significant impact of a fiber rich diet for the prevention of heart disease. By focusing on the science behind how fiber, both soluble and insoluble can lead to lower rates of heart disease, this important reference will educate researchers, cardiologists, medical providers and students on how to improve patients’ hearts via a fiber rich diet. Coverage includes the known mechanisms of how fiber works to reduce insulin resistance, control weight, reduce cholesterol by binding with bile, maintain stable glucose levels and influence gut microflora. Explains how fiber affects cardiovascular disease through the influence on insulin resistance, reduction of cholesterol, change in gut microflora and in weight control Provides thorough coverage of the effect of fiber on arrhythmias and valvular abnormalities Includes information on the indirect relationship between constipation and heart disease

Vascular Smooth Muscle

Author: Chi-Ming Hai
Publisher: World Scientific
ISBN: 9813144076
Size: 50.92 MB
Format: PDF, ePub
View: 6844
This book presents key concepts in the structure and function of vascular smooth muscle cells in health and disease. Supplemental reading may be drawn from the extensive references listed at the end of each chapter. Vascular smooth muscle cell is the major cell type in blood vessels. Dysfunction of vascular smooth muscle cells is an important cause of vascular diseases, for example, atherosclerosis, hypertension, and circulatory shock. Vascular smooth muscle cells are phenotypically plastic, capable of switching between two major phenotypes — contractile/differentiated phenotype and invasive/proliferative phenotype in response to environmental clues. Chapter 1 introduces the major areas of research presented in this monograph. Chapters 2 to 4 address the structure and function of the contractile/differentiated phenotype of vascular smooth muscle cell. Chapters 5 and 6 address the developmental basis of vascular smooth muscle cell phenotype and structure and function of podosomes (invasive organelles) in the invasive/proliferative phenotype of vascular smooth muscle cell. Chapters 7 to 9 address the role of vascular smooth muscle cell dysfunction in vascular diseases — atherosclerosis, hypertension, and circulatory shock. Contents:Introduction (Chi-Ming Hai)Structure of Differentiated/Contractile Vascular Smooth Muscle Cells (Thomas J Eddinger)Vascular Structure and Function (Paul H Ratz)Actin Filament Dynamics During Vascular Smooth Muscle Contraction (William C Cole and Michael P Walsh)Developmental Basis of Vascular Smooth Muscle Cell Phenotypes (Christine Cheung and B C Narmada)Regulation of Podosomes in Vascular Smooth Muscle Cell Invasion of the Extracellular Matrix (Alan Mak)Vascular Smooth Muscle Cell Proliferation and Invasion in Atherosclerosis (Chi-Ming Hai)The Role of Non-Coding RNA in the Control of Vascular Contractility and Disease (C J Nicholson and K G Morgan)Vascular Smooth Muscle Cells as Therapeutic Target for the Treatment of Circulatory Shock (Liangming Liu, Tao Li and Chengyang Duan) Readership: This book will be a useful reference for graduate students, post-doctoral fellows, and scientists who work on vascular biology, as well as physicians who work on vascular medicine.

Spinal Muscular Atrophy

Author: Charlotte J Sumner
Publisher: Academic Press
ISBN: 0128036869
Size: 37.70 MB
Format: PDF, Kindle
View: 5992
Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Mechanisms Of Vascular Disease

Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Size: 62.26 MB
Format: PDF
View: 3121
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

A Comprehensive Guide To Geriatric Rehabilitation

Author: Timothy L. Kauffman
Publisher: Elsevier Health Sciences
ISBN: 0702060585
Size: 68.42 MB
Format: PDF
View: 3541
Now in its third edition, this trusted clinical guide enables both the busy practitioner and student to review or to learn about a range of pathologies, conditions, examinations, diagnostic procedures, and interventions that can be effectively used in the physical rehabilitation of older people. It presents a broad overview of age-related physiological changes as well as specific professional discipline perspectives. Organized into eleven distinct and interrelated units, the first unit begins with key anatomical and physiological considerations seen with aging which have significant impact on the older person. The second and third units go on to review important aging-related conditions and disorders of the musculoskeletal and neuromuscular/neurological systems respectively. Neoplasms commonly encountered in older people are the focus of the fourth unit; while aging-related conditions of the cardiovascular, pulmonary, integumentary and sensory systems are presented in units five through seven. Unit eight highlights a range of specific clinical problems and conditions commonly encountered with older patients. Critically, all of these units emphasize important examination and diagnostic procedures needed for a thorough evaluation and stress interventions that can be of significant benefit to the older patient. The ninth unit presents select physical therapeutic interventions that are especially important in managing rehabilitative care. Key societal issues related to aging are discussed in the tenth unit. Finally, the concluding eleventh unit focuses on the successful rehabilitation team that includes both professional and non-professional caregiver members. A trusted guide to the conditions and problems faced when evaluating and treating geriatric patients Extensive coverage over 84 chapters, each written by an expert in the field Includes imaging, vision and the aging ear Cross-referenced - providing the complexity and inter-relatedness of co-morbidities common to aging patients Collaborative international perspective Chapters on the aging spine; frailty; safe pilates for bone health; health care for older people Additional renowned editor - Ronald W. Scott Revised title to reflect the comprehensive scope of content covered (previously entitled Geriatric Rehabilitation Manual)

Skeletal Muscle Structure Function And Plasticity

Author: Richard L. Lieber
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781730617
Size: 64.38 MB
Format: PDF, ePub
View: 7631
In its Second Edition, this text addresses basic and applied physiological properties of skeletal muscle in the context of the physiological effects from clinical treatment. Many concepts are expanded and recent studies on human muscle have been added. This new edition also includes more clinically relevant cases and stories. A two-page full color insert of muscle sections is provided to ensure integral understanding of the concepts presented in the text. Anyone interested in human movement analysis and the understanding of generation and control from the musculoskeletal and neuromuscular systems in implementing movement will find this a valuable resource.

Pathology Of Domestic Animals

Author: M. Grant Maxie
Publisher: Saunders Limited
Size: 28.19 MB
Format: PDF, Kindle
View: 6107
Rev ed. of: Pathology of domestic animals / K.V.F. Jubb, Peter C. Kennedy, Nigel Palmer. 4th ed. c1993.

Ion Channels In Health And Disease

Author: Geoffrey S. Pitt
Publisher: Academic Press
ISBN: 0128020172
Size: 28.77 MB
Format: PDF
View: 1778
Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues