Microfluidics And Nanotechnology

Author: Eric Lagally
Publisher: CRC Press
ISBN: 1466594918
Size: 60.94 MB
Format: PDF
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An increasing number of technologies are being used to detect minute quantities of biomolecules and cells. However, it can be difficult to determine which technologies show the most promise for high-sensitivity and low-limit detection in different applications. Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit details proven approaches for the detection of single cells and even single molecules—approaches employed by the world’s foremost microfluidics and nanotechnology laboratories. While similar books concentrate only on microfluidics or nanotechnology, this book focuses on the combination of soft materials (elastomers and other polymers) with hard materials (semiconductors, metals, and glass) to form integrated detection systems for biological and chemical targets. It explores physical and chemical—as well as contact and noncontact—detection methods, using case studies to demonstrate system capabilities. Presenting a snapshot of the current state of the art, the text: Explains the theory behind different detection techniques, from mechanical resonators for detecting cell density to fiber-optic methods for detecting DNA hybridization, and beyond Examines microfluidic advances, including droplet microfluidics, digital microfluidics for manipulating droplets on the microscale, and more Highlights an array of technologies to allow for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit not only serves as a quick reference for the latest achievements in biochemical detection at the single-cell and single-molecule levels, but also provides researchers with inspiration for further innovation and expansion of the field.

Testing For Small Delay Defects In Nanoscale Cmos Integrated Circuits

Author: Sandeep K. Goel
Publisher: CRC Press
ISBN: 1351833707
Size: 56.26 MB
Format: PDF, Kindle
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Advances in design methods and process technologies have resulted in a continuous increase in the complexity of integrated circuits (ICs). However, the increased complexity and nanometer-size features of modern ICs make them susceptible to manufacturing defects, as well as performance and quality issues. Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits covers common problems in areas such as process variations, power supply noise, crosstalk, resistive opens/bridges, and design-for-manufacturing (DfM)-related rule violations. The book also addresses testing for small-delay defects (SDDs), which can cause immediate timing failures on both critical and non-critical paths in the circuit. ? Overviews semiconductor industry test challenges and the need for SDD testing, including basic concepts and introductory material Describes algorithmic solutions incorporated in commercial tools from Mentor Graphics Reviews SDD testing based on "alternative methods" that explores new metrics, top-off ATPG, and circuit topology-based solutions Highlights the advantages and disadvantages of a diverse set of metrics, and identifies scope for improvement Written from the triple viewpoint of university researchers, EDA tool developers, and chip designers and tool users, this book is the first of its kind to address all aspects of SDD testing from such a diverse perspective. The book is designed as a one-stop reference for current industrial practices, research challenges in the domain of SDD testing, and recent developments in SDD solutions.

Diagnostic Devices With Microfluidics

Author: Francesco Piraino
Publisher: CRC Press
ISBN: 1351650483
Size: 47.11 MB
Format: PDF, ePub, Docs
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This book provides a current view of the research and commercial landscape of diagnostics devices, particularly those that utilize microscale technologies, intended for both patient and laboratory use. Common diagnostic devices that are based on microfluidic principles include glucose sensors for diabetic patients and over-the-counter pregnancy tests. Other diagnostic devices are being developed to quickly test a patient for bacterial and viral infections, and other diseases. The chapters, written by experts from around the world, discuss how to fabricate, apply, and market microfluidic diagnostic chips – for lab and at-home use. Most importantly, the book also contains a discussion of topics relevant to the private sector, including patient-focused, market-oriented development of diagnostics devices.

Lab On A Chip Devices And Micro Total Analysis Systems

Author: Jaime Castillo-León
Publisher: Springer
ISBN: 3319086871
Size: 42.18 MB
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This book covers all the steps in order to fabricate a lab-on-a-chip device starting from the idea, the design, simulation, fabrication and final evaluation. Additionally, it includes basic theory on microfluidics essential to understand how fluids behave at such reduced scale. Examples of successful histories of lab-on-a-chip systems that made an impact in fields like biomedicine and life sciences are also provided. This book also: · Provides readers with a unique approach and toolset for lab-on-a-chip development in terms of materials, fabrication techniques, and components · Discusses novel materials and techniques, such as paper-based devices and synthesis of chemical compounds on-chip · Covers the four key aspects of development: basic theory, design, fabrication, and testing · Provides readers with a comprehensive list of the most important journals, blogs, forums, and conferences where microfluidics and lab-on-a-chip news, methods, techniques and challenges are presented and discussed, as well as a list of companies providing design and simulation support, components, and/or developing lab-on-a-chip and microfluidic devices.

Microfluidics For Advanced Functional Polymeric Materials

Author: Liang-Yin Chu
Publisher: John Wiley & Sons
ISBN: 352734182X
Size: 28.85 MB
Format: PDF, ePub
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A comprehensive and systematic treatment of our current understanding of the microfluidic technique and its advantages in the controllable fabrication of advanced functional polymeric materials. Introducing and summarizing recent advances and achievements in the field, the authors cover the design and fabrication of microfluidic devices, the fundamentals and strategies for controllable microfluidic generation of multiphase liquid systems, and the use of these liquid systems with an elaborate combination of their structures and compositions for generating novel polymer materials, such as microcapsules, microfibers, valves, and membranes. Clear diagrams and illustrations throughout the text make the relevant theory and technologies more readily accessible. The result is a specialist reference for materials scientists, organic, polymer and physical chemists, and chemical engineers.

Electrochemical Biosensors

Author: Serge Cosnier
Publisher: CRC Press
ISBN: 9814411477
Size: 50.71 MB
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Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analytical chemistry. In particular, electrochemistry has played a pivotal role in the development of transduction methods for biological processes and biosensors. In parallel, the explosion of activity in nanoscience and nanotechnology and their huge success have profoundly affected biosensor technology, opening new avenues of research for electrode materials and transduction. This book provides an overview of biosensors based on amperometry, conductimetry, potentiometry, square-wave voltammetry, impedance, and electrochemiluminescence and describes the use of ultramicroelectrodes for the real-time monitoring and understanding of exocytosis. Areas of particular interest are the use of silver and gold nanoparticles for signal amplification, photocurrent transduction, and aptamer design. Moreover, advanced insights in the innovative concept of self-powered biosensors derived from biofuel cells are also discussed.

Electrogenerated Chemiluminescence

Author: Allen J. Bard
Publisher: CRC Press
ISBN: 9780203027011
Size: 16.82 MB
Format: PDF
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The first source on this expanding analytical science, this reference explores advances in the instrumentation, design, and application of techniques with electrogenerated chemiluminescence (ECL), examining the use and impact of ECL-based assays in clinical diagnostics, life science research, environmental testing, food and water evaluation, and the detection of biowarfare agents. Compiled by the pioneer of this highly innovative technology, this volume provides contributions from 16 leading authorities. They discuss the simulation of ECL behavior using commercial software, summarize key characteristics of organic ECL systems, and cover developments in metal chelate ECL.

Nanotechnology Principles And Fundamentals

Author: Günter Schmid
Publisher: Wiley-VCH
ISBN: 9783527317325
Size: 51.27 MB
Format: PDF
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The ultimate reference book, providing an in-depth introduction to nanotechnology, discussing topics from ethics and philosophy to challenges faced by this up-and-coming industry, all in one comprehensive volume. The topic could not be hotter, Nanotechnology is the new technology drive of the 21st century paired with existing, multibillion dollar markets and fundings. The entire reference set of 9 volumes gives an excellent, in-depth overview of everything you need to know about nanotechnology and nanoscience with each volume dedicated to a specific topic which is covered in detail by experts from that particular field.

Digitally Assisted Pipeline Adcs

Author: Boris Murmann
Publisher: Springer Science & Business Media
ISBN: 1402078404
Size: 47.67 MB
Format: PDF, Mobi
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Digitally Assisted Pipeline ADCs: Theory and Implementation explores the opportunity to reduce ADC power dissipation by leveraging digital signal processing capabilities in fine line integrated circuit technology. The described digitally assisted pipelined ADC uses a statistics-based system identification technique as an enabling element to replace precision residue amplifiers with simple open-loop gain stages. The digital compensation of analog circuit distortion eliminates one key factor in the classical noise-speed-linearity constraint loop and thereby enables a significant power reduction. Digitally Assisted Pipeline ADCs: Theory and Implementation describes in detail the implementation and measurement results of a 12-bit, 75-MSample/sec proof-of-concept prototype. The Experimental converter achieves power savings greater than 60% over conventional implementations. Digitally Assisted Pipeline ADCs: Theory and Implementation will be of interest to researchers and professionals interested in advances of state-of-the-art in A/D conversion techniques.

Introduction To Biomems

Author: Albert Folch
Publisher: CRC Press
ISBN: 1466509384
Size: 73.20 MB
Format: PDF, ePub, Mobi
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The entire scope of the BioMEMS field—at your fingertips Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms. Brilliant color presentation Avoiding the overwhelming details found in many engineering and physics texts, this groundbreaking book—in color throughout—includes only the most essential formulas as well as many noncalculation-based exercises. Important terms are highlighted in bold and defined in a glossary. The text contains more than 400 color figures, most of which are from the original researchers. Coverage of both historical perspectives and the latest developments Developed from the author’s long-running course, this classroom-tested text gives readers a vivid picture of how the field has grown by presenting historical perspectives and a timeline of seminal discoveries. It also describes numerous state-of-the-art biomedical applications that benefit from "going small," including devices that record the electrical activity of brain cells, measure the diffusion of molecules in microfluidic channels, and allow for high-throughput studies of gene expression.