Applied Epidemiology And Biostatistics

Author: Giuseppe La Torre
Publisher: SEEd
ISBN: 9788889688564
Size: 23.52 MB
Format: PDF, ePub
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This book provides not only the theory of biostatistics, but also the opportunity of applying it in practice. In fact, each chapter presents one or more specific examples on how to perform an epidemiological or statistical data analysis and includes download access to the software and databases, giving the reader the possibility of replicating the analyses described.

Small Clinical Trials

Author: Committee on Strategies for Small-Number-Participant Clinical Research Trials
Publisher: National Academies Press
ISBN: 0309073332
Size: 29.49 MB
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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Clinical Epidemiology Evidence Based Medicine

Author: David L. Katz
Publisher: SAGE
ISBN: 0761919392
Size: 67.50 MB
Format: PDF, ePub, Mobi
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Using clinical examples and citing liberally from the peer-reviewed literature, this book shows how statistical priniciples can improve medical decisions.

Statistical Analysis Of Epidemiologic Data

Author: S. Selvin
Publisher: Oxford University Press, USA
ISBN:
Size: 70.64 MB
Format: PDF, ePub, Mobi
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This book combines applied and theoretical approaches to the analysis of epidemiologic issues. It goes beyond elementary material to deal with real problems generated by disease data, and delves into less usual areas such as the analysis of spatial distributions, survival data, proportional hazards regression, and "computer-intensive" approaches to statistical estimation. Each method discussed in the text is illustrated with examples which include complete sets of data. Using actual data demonstrates the strengths and weaknesses of different analytic approaches in describing a disease process. The goal of the book is to allow the reader to develop a clear understanding of analytic approaches to problems in epidemiologic data analysis without relying on sophisticated mathematics and advanced statistical theory. For the Second Edition a new chapter on the analysis of matched data has been added. This covers both discrete and continuous outcomes and explains both the classic analytic approach and the conditional logistic regression model. New sections have also been added on contingency table data, misclassification, and additive models underlying tabular data. In all the chapters there are new applications and other revisions that make this Second Edition a clearer and more helpful exposition of the way statistical tools are used to analyze epidemiologic data.

Basic Epidemiology

Author: R. Bonita
Publisher: World Health Organization
ISBN: 9241547073
Size: 22.16 MB
Format: PDF, ePub
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Basic epidemiology provides an introduction to the core principles and methods of epidemiology, with a special emphasis on public health applications in developing countries. This edition includes chapters on the nature and uses of epidemiology; the epidemiological approach to defining and measuring the occurrence of health-related states in populations; the strengths and limitations of epidemiological study designs; and the role of epidemiology in evaluating the effectiveness and efficiency of health care. The book has a particular emphasis on modifiable environmental factors and encourages the application of epidemiology to the prevention of disease and the promotion of health, including environmental and occupational health.

Practical Statistics For Medical Research

Author: Douglas G. Altman
Publisher: CRC Press
ISBN: 9780412276309
Size: 69.37 MB
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Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research. Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Clinical Epidemiology

Author: Noel S. Weiss
Publisher: Monographs in Epidemiology and
ISBN: 9780195305234
Size: 20.48 MB
Format: PDF
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Examining the principles and methods of research on the evaluation of factors affecting the outcome of illness, this volume emphasizes diagnostic and therapeutic interventions - the factors most readily modified by health care providers. The author discusses various ways of structuring observations on patient groups and appraises the nature and strength of inferences drawn from those observations. Weiss also demonstrates how the results of this type of research - clinical epidemiologic research - can be incorporated into the decision-making process utilized in clinical medicine." Among other changes, this new edition of Clinical Epidemiology greatly expands the chapter on randomized controlled trials and includes a whole new chapter on meta-analysis, authored by Peter Cummings with Noel S. Weiss. Meta-analysis, the statistical synthesis of data from comparable studies, was unheard of thirty years ago, but with the advent of increased computer technology, the method has been steadily growing in importance in the interpretation of the results of patient-oriented medical research. Clinical Epidemiology is an essential reference guide to the quantitative assessment of the consequences of illness for clinicians in training or in practice.

Epa 630 R

Author: United States. Environmental Protection Agency. Risk Assessment Forum
Publisher:
ISBN:
Size: 29.21 MB
Format: PDF, Kindle
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