Introducing Proteomics

Author: Josip Lovric
Publisher: John Wiley & Sons
ISBN: 1119957192
Size: 69.12 MB
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Introducing Proteomics gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences. This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study. The text covers the following: Separation Technologies Analysis of Peptides/Proteins by Mass Spectrometry Strategies in Proteomics This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, Introducing Proteomics includes extensive references and a list of relevant proteomics information sources; essential for any student. This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems. "I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues." —Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website www.wiley.com/go/lovric

Computational Methods For Mass Spectrometry Proteomics

Author: Ingvar Eidhammer
Publisher: John Wiley & Sons
ISBN: 9780470724293
Size: 50.46 MB
Format: PDF
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Proteomics is the study of the subsets of proteins present in different parts of an organism and how they change with time and varying conditions. Mass spectrometry is the leading technology used in proteomics, and the field relies heavily on bioinformatics to process and analyze the acquired data. Since recent years have seen tremendous developments in instrumentation and proteomics-related bioinformatics, there is clearly a need for a solid introduction to the crossroads where proteomics and bioinformatics meet. Computational Methods for Mass Spectrometry Proteomics describes the different instruments and methodologies used in proteomics in a unified manner. The authors put an emphasis on the computational methods for the different phases of a proteomics analysis, but the underlying principles in protein chemistry and instrument technology are also described. The book is illustrated by a number of figures and examples, and contains exercises for the reader. Written in an accessible yet rigorous style, it is a valuable reference for both informaticians and biologists. Computational Methods for Mass Spectrometry Proteomics is suited for advanced undergraduate and graduate students of bioinformatics and molecular biology with an interest in proteomics. It also provides a good introduction and reference source for researchers new to proteomics, and for people who come into more peripheral contact with the field.

Mass Spectrometry For The Novice

Author: John Greaves
Publisher: CRC Press
ISBN: 1420094203
Size: 58.99 MB
Format: PDF
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With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques. The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entrée to mass spectrometry. A CD-ROM with selected figures and cartoons is included.

Principles Of Proteomics

Author: Richard M. Twyman
Publisher: Garland Science
ISBN: 131775302X
Size: 44.29 MB
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Principles of Proteomics, Second Edition, provides a concise and user-friendly introduction to the diverse technologies used for the large-scale analysis of proteins, as well as their applications, and their impact in areas such as drug discovery, agriculture, and the fight against disease. Proteomics is a fast-advancing field in which researchers seek to capture all the proteins in the cell and characterize them in ever more detail. Principles of Proteomics has been fully updated to reflect the most recent developments in the field without losing its focus on the underlying principles. With worked examples, case studies profiling both established and emerging technologies, and further reading lists for each chapter, Principles of Proteomics is an ideal introduction for students, researchers and those working in the industry.

Quantitative Proteomics By Mass Spectrometry

Author: Salvatore Sechi
Publisher: Springer Science & Business Media
ISBN: 1597452556
Size: 38.17 MB
Format: PDF, Kindle
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Quantitative Proteomics describes in detail the methods and protocols used for many of the most significant recent developments in this field. Mass spectrometry is covered in this book, discussing its major role in proteomics and it being an essential tool for studying complex biological systems and diseases.

Mass Spectrometry

Author: Edmond de Hoffmann
Publisher: John Wiley & Sons
ISBN: 1118681940
Size: 33.54 MB
Format: PDF, ePub
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The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

Introduction To Proteomics

Author: Daniel Liebler
Publisher: Springer Science & Business Media
ISBN: 9780896039919
Size: 35.45 MB
Format: PDF, Mobi
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Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Mass Spectrometry For Biotechnology

Author: Gary Siuzdak
Publisher: Elsevier
ISBN: 0080535844
Size: 15.61 MB
Format: PDF, Docs
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If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics. Glossary of basic terms Abundant illustrations Examples of applications Practical tips on using mass spectrometric techniques Useful for peptide, protein, oligonucleotide, and carbohydrate analysis Simplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI) Electrospray Ionization (ESI) Fast Atom/Ion Bombardment (FAB)

Proteomics

Author: Andrew J. Link
Publisher:
ISBN: 9780879697877
Size: 71.47 MB
Format: PDF, ePub, Mobi
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Based on a popular course at Cold Spring Harbor Laboratory, this new manual assembles cutting–edge protocols, helpful hints, and lecture notes to teach researchers from a variety of disciplines the essential methods of proteomics. It provides well–illustrated descriptions of experimental procedures, detailed protocols involving state–of–the–art instrumentation, and lists of recommended Web sites and reading material. It can be used as the basis for a course or as a detailed bench manual, and is indispensable for those performing proteomic experiments.

Undergraduate Instrumental Analysis Seventh Edition

Author: James W. Robinson
Publisher: CRC Press
ISBN: 1482233746
Size: 31.53 MB
Format: PDF, ePub, Docs
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Crucial to research in molecular biology, medicine, geology, food science, materials science, and many other fields, analytical instrumentation is used by many scientists and engineers who are not chemists. Undergraduate Instrumental Analysis, Seventh Edition provides users of analytical instrumentation with an understanding of these instruments, covering all major fields of modern instrumentation. Following the tradition of earlier editions, this text is designed for teaching undergraduates and those with no analytical chemistry background how contemporary analytical instrumentation works, as well as its uses and limitations. Each chapter provides a discussion of the fundamental principles underlying the techniques, descriptions of the instrumentation, and numerous applications. The chapters also contain updated bibliographies and problems, and most have suggested experiments appropriate to the techniques. This completely revised and updated edition covers subjects in more detail, such as a completely revised x-ray chapter, expanded coverage of electroanalytical techniques, and expansion of chromatography and mass spectrometry topics to reflect the predominance of these instruments in laboratories. This includes state-of-the-art sample introduction and mass analyzers, and the latest developments in UPLC and hyphenated techniques. The book also contains new graphics and addresses several new topics: Ion mobility spectrometry Time domain NMR (relaxometry) Electron spin resonance spectroscopy (ESR, EPR) Forensic science and bioanalytical applications Microcalorimetry and optical thermal instruments Laser-induced breakdown spectroscopy (LIBS) This text uniquely combines instrumental analysis with organic spectral interpretation (IR, NMR, and MS). It provides detailed coverage of sampling, sample handling, sample storage, and sample preparation. In addition, the authors have included many instrument manufacturers’ websites, which contain extensive resources.