Handbook Of Single Molecule Biophysics

Author: Peter Hinterdorfer
Publisher: Springer Science & Business Media
ISBN: 9780387764979
Size: 66.84 MB
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This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.

Handbook Of Single Molecule Fluorescence Spectroscopy

Author: Chris Gell
Publisher: OUP Oxford
ISBN: 9780198529422
Size: 44.74 MB
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This book is aimed at providing a practical introduction to single molecule fluorescence experiments, the analysis of the data, and applications of the techniques to the study of biological structure and function. The techniques have wide applications in biology, and underpin some aspects of nanotechnology and quantum information processing.

Handbook Of Molecular Biophysics

Author: Henrik G. Bohr
Publisher: John Wiley & Sons
ISBN: 3527407022
Size: 54.58 MB
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This handbook and reference condenses the biophysics contents of the renowned Encyclopedia of Applied Physics in one handy volume. Twenty-eight carefully written overview articles cover the latest research, including single molecule spectroscopy, biosensors and cellular biomechanics. Readers benefit from concise summaries of the fundamentals, methods and applications, backed by detailed tables of contents for quick access, and glossaries of terms, as well as detailed lists of references and further reading. For libraries and research and development teams in academia and industry. From the contents: Quantum Mechanics Methods for Molecular Biophysics and Electronic Structure Calculations of Biomolecules Studies of Motions of Biomolecules and Molecular Dynamics Calculations Biomolecular Structures and Dynamics in Proteins, Lipids, and DNA Radiation and Spectroscopy Methods in Molecular Biophysics Neurobiophysics and Ion Channels Techniques for Detecting Molecular Structures down to the Single Molecule Level Physical Effects in Biomolecules and larger Organic Systems Molecular Biophysics Applications in Medicine

Handbook Of Molecular Force Spectroscopy

Author: Aleksandr Noy
Publisher: Springer Science & Business Media
ISBN: 038749989X
Size: 64.46 MB
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Researchers in academia and industry who are interested in techniques for measuring intermolecular forces will find this an essential text. It presents a review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The handbook begins with a review of the fundamental physics of loading single and multiple chemical bonds on the nanometer scale. It contains a discussion of thermodynamic and kinetic models of binding forces and dissipation effects in nanoscale molecular contacts, covers practical aspects of modern single-molecule level techniques, and concludes with applications of force spectroscopy to chemical and biological processes. Computer modeling of force spectroscopy experiments is also addressed.

Single Molecule Biophysics And Poisson Process Approach To Statistical Mechanics

Author: Susanta K Sarkar
Publisher: Morgan & Claypool Publishers
ISBN: 1681741164
Size: 67.54 MB
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This is an overview of single molecule physics, the study of both equilibrium and non-equilibrium properties at the single molecule level. It begins with an introduction to this fascinating science and includes a chapter on how to build the most popular instrument for single molecule biophysics, the total internal reflection fluorescence (TIRF) microscope. It concludes with the Poisson process approach to statistical mechanics, explaining how to relate the process to diverse areas and see how data analysis and error bars are integral parts of science.

Advances In Chemical Physics Volume 146

Author: Tamiki Komatsuzaki
Publisher: John Wiley & Sons
ISBN: 111813138X
Size: 32.31 MB
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Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.

Single Molecule Cellular Biophysics

Author: Mark C. Leake
Publisher: Cambridge University Press
ISBN: 1139619349
Size: 51.65 MB
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Recent advances in single molecule science have presented a new branch of science: single molecule cellular biophysics, combining classical cell biology with cutting-edge single molecule biophysics. This textbook explains the essential elements of this new discipline, from the state-of-the-art single molecule techniques to real-world applications in unravelling the inner workings of the cell. Every effort has been made to ensure the text can be easily understood by students from both the physical and life sciences. Mathematical derivations are kept to a minimum whilst unnecessary biological terminology is avoided and text boxes provide readers from either background with additional information. 100 end-of-chapter exercises are divided into those aimed at physical sciences students, those aimed at life science students and those that can be tackled by students from both disciplines. The use of case studies and real research examples make this textbook indispensable for undergraduate students entering this exciting field.

Single Particle Tracking And Single Molecule Energy Transfer

Author: Christoph Bräuchle
Publisher: John Wiley & Sons
ISBN: 9783527628377
Size: 41.79 MB
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Closing a gap in the literature, this handbook gathers all the information on single particle tracking and single molecule energy transfer. It covers all aspects of this hot and modern topic, from detecting virus entry to membrane diffusion, and from protein folding using spFRET to coupled dye systems, as well recent achievements in the field. Throughout, the first-class editors and top international authors present content of the highest quality, making this a must-have for physical chemists, spectroscopists, molecular physicists and biochemists.

Handbook Of Dynein

Author: Keiko Hirose
Publisher: CRC Press
ISBN: 981430333X
Size: 59.64 MB
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This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students. Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.