Guidelines For Process Safety In Bioprocess Manufacturing Facilities

Author: CCPS (Center for Chemical Process Safety)
Publisher: John Wiley & Sons
ISBN: 1118009002
Size: 57.80 MB
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This book helps advance process safety in a key area of interest. Currently, no literature exists which is solely dedicated to process safety for the bioprocessing industry. There are texts, guidelines, and standards on biosafety at the laboratory level and for industrial hygiene, but no guidelines for large-scale production facilities. In fact, biosafety is largely defined as a field that promotes safe laboratory practices, procedures and use of containment equipment and facilities. Additionally, biomedical engineers, biologists, or other professionals without chemical engineering training or knowledge of inherently safe design are designing many of these facilities.

Biopharmaceutical Processing

Author: Gunter Jagschies
Publisher: Elsevier
ISBN: 0128125527
Size: 44.56 MB
Format: PDF
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Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference

Guidelines For Risk Based Process Safety

Author: Center for Chemical Process Safety (CCPS)
Publisher: John Wiley & Sons
ISBN: 0470165693
Size: 62.10 MB
Format: PDF, Mobi
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Guidelines for Risk Based Process Safety provides guidelines for industries that manufacture, consume, or handle chemicals, by focusing on new ways to design, correct, or improve process safety management practices. This new framework for thinking about process safety builds upon the original process safety management ideas published in the early 1990s, integrates industry lessons learned over the intervening years, utilizes applicable "total quality" principles (i.e., plan, do, check, act), and organizes it in a way that will be useful to all organizations - even those with relatively lower hazard activities - throughout the life-cycle of a company.

Process Architecture In Biomanufacturing Facility Design

Author: Jeffery Odum
Publisher: John Wiley & Sons
ISBN: 1118833651
Size: 19.49 MB
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Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature—and it’s rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements. Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future. Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO—especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.

Handbook Of Industrial Chemistry And Biotechnology

Author: James A. Kent
Publisher: Springer Science & Business Media
ISBN: 1461442591
Size: 43.83 MB
Format: PDF, Mobi
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Substantially revising and updating the classic reference in the field, this handbook offers a valuable overview and myriad details on current chemical processes, products, and practices. No other source offers as much data on the chemistry, engineering, economics, and infrastructure of the industry. The Handbook serves a spectrum of individuals, from those who are directly involved in the chemical industry to others in related industries and activities. It provides not only the underlying science and technology for important industry sectors, but also broad coverage of critical supporting topics. Industrial processes and products can be much enhanced through observing the tenets and applying the methodologies found in chapters on Green Engineering and Chemistry (specifically, biomass conversion), Practical Catalysis, and Environmental Measurements; as well as expanded treatment of Safety, chemistry plant security, and Emergency Preparedness. Understanding these factors allows them to be part of the total process and helps achieve optimum results in, for example, process development, review, and modification. Important topics in the energy field, namely nuclear, coal, natural gas, and petroleum, are covered in individual chapters. Other new chapters include energy conversion, energy storage, emerging nanoscience and technology. Updated sections include more material on biomass conversion, as well as three chapters covering biotechnology topics, namely, Industrial Biotechnology, Industrial Enzymes, and Industrial Production of Therapeutic Proteins.

Fermentation And Biochemical Engineering Handbook

Author: Celeste M. Todaro
Publisher: William Andrew
ISBN: 1455730467
Size: 22.56 MB
Format: PDF, ePub, Mobi
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A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes—data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels. New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained. Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation Industrial contributors from leading global companies, including Merck, Eli Lilly, Amgen, and Bristol-Myers Squibb Covers synthetic processes for both small and large molecules

Biosecurity

Author: Ryan Burnette
Publisher: John Wiley & Sons
ISBN: 047061417X
Size: 64.87 MB
Format: PDF
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"This book defines the concepts of biosecurity, biosafety, and biosurety and shows how they relate to one another under the overall framework of biodefense. The book also addresses biosecurity strategies for non-laboratory settings, including private sector facilities, the transportation infrastructure, and the food and agriculture sector including insurance, healthcare, the global supply chain, and agriculture. Discussions also include bioterrorism, biosecurity operations, various existing biosecurity programs, and biosecurity ethics. Designed to reach a wide variety of professionals, this resource provides a balanced and accessible look at biodefense and its applications"--

Process Plant Equipment

Author: Michael D. Holloway
Publisher: John Wiley & Sons
ISBN: 1118162544
Size: 53.10 MB
Format: PDF, ePub
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“Process Plant Equipment Book is another great publication from Wiley as a reference book for final year students as well as those who will work or are working in chemical production plants and refinery…” -Associate Prof. Dr. Ramli Mat, Deputy Dean (Academic), Faculty of Chemical Engineering, Universiti Teknologi Malaysia “…give[s] readers access to both fundamental information on process plant equipment and to practical ideas, best practices and experiences of highly successful engineers from around the world… The book is illustrated throughout with numerous black & white photos and diagrams and also contains case studies demonstrating how actual process plants have implemented the tools and techniques discussed in the book. An extensive list of references enables readers to explore each individual topic in greater depth…” –Stainless Steel World and Valve World, November 2012 Discover how to optimize process plant equipment, from selection to operation to troubleshooting From energy to pharmaceuticals to food, the world depends on processing plants to manufacture the products that enable people to survive and flourish. With this book as their guide, readers have the information and practical guidelines needed to select, operate, maintain, control, and troubleshoot process plant equipment so that it is efficient, cost-effective, and reliable throughout its lifetime. Following the authors' careful explanations and instructions, readers will find that they are better able to reduce downtime and unscheduled shutdowns, streamline operations, and maximize the service life of processing equipment. Process Plant Equipment: Operation, Control, and Reliability is divided into three sections: Section One: Process Equipment Operations covers such key equipment as valves, pumps, cooling towers, conveyors, and storage tanks Section Two: Process Plant Reliability sets forth a variety of tested and proven tools and methods to assess and ensure the reliability and mechanical integrity of process equipment, including failure analysis, Fitness-for-Service assessment, engineering economics for chemical processes, and process component function and performance criteria Section Three: Process Measurement, Control, and Modeling examines flow meters, process control, and process modeling and simulation Throughout the book, numerous photos and diagrams illustrate the operation and control of key process equipment. There are also case studies demonstrating how actual process plants have implemented the tools and techniques discussed in the book. At the end of each chapter, an extensive list of references enables readers to explore each individual topic in greater depth. In summary, this text offers students, process engineers, and plant managers the expertise and technical support needed to streamline and optimize the operation of process plant equipment, from its initial selection to operations to troubleshooting.

Current Developments In Biotechnology And Bioengineering

Author: Christian Larroche
Publisher: Elsevier
ISBN: 0444636749
Size: 58.28 MB
Format: PDF, Mobi
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Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, reviewing industrial biotechnology and bioengineering practices that facilitate and enhance the transition of processes from lab to plant scale, which is becoming increasingly important as such transitions continue to grow in frequency. Focusing on industrial bioprocesses, bioreactors for bioprocesses, and controls for bioprocesses, this title reviews industrial practice to identify bottlenecks and propose solutions, highlighting that the optimal control of a bioprocess involves not only maximization of product yield, but also taking into account parameters such as quality assurance and environmental aspects. Describes industrial bioprocesses based on the reaction media Lists the type of bioreactors used for a specific bioprocess/application Outlines the principles of control systems in various bioprocesses