Genomics Circuits And Pathways In Clinical Neuropsychiatry

Author: Thomas Lehner
Publisher: Academic Press
ISBN: 0128005300
Size: 17.44 MB
Format: PDF
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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

The Behavioral Neurology Of Dementia

Author: Bruce L. Miller
Publisher: Cambridge University Press
ISBN: 1316688100
Size: 72.22 MB
Format: PDF, Kindle
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This new edition of The Behavioral Neurology of Dementia provides clinicians and researchers with the latest research findings written by the leading dementia experts. With chapters ranging from cognitive evaluation to imaging, and genetics and pathology to treatment, the detailed clinical descriptions of diseases and symptoms serve not only as an educational tool for trainees, but also as an opportunity for experienced clinicians to deepen their knowledge and better serve their patients. After years of little progress, the pace of discovery has been speeding up in the last decade, and the authors distil the most valuable discoveries into clear, insightful chapters with applicable information. All the chapters from the first edition have been refreshed with new text and figures. There are new chapters on autoimmune antibody-associated encephalopathy; chronic traumatic encephalopathy; and sleep issues in dementia.

Functional Neuromarkers For Psychiatry

Author: Juri D. Kropotov
Publisher: Academic Press
ISBN: 0124105203
Size: 60.77 MB
Format: PDF
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Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results. Identifies specific brain activation patterns that are neuromarkers for psychiatric disorders Includes neuromarkers as seen via fMRI, PET, qEEG, and ERPs Addresses neuromarkers for ADHD, schizophrenia, and OCD in detail Provides information on using neuromarkers for diagnosis and/or personalized treatment

Developing Therapeutics For Alzheimer S Disease

Author: Michael S. Wolfe
Publisher: Academic Press
ISBN: 0128021640
Size: 63.78 MB
Format: PDF, Docs
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Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Anatomy Of Delusion

Author: Henry Kellerman
Publisher: Lantern Books
ISBN: 1590564332
Size: 57.47 MB
Format: PDF, ePub, Mobi
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There exist a plethora of definitions to the concept of delusion. Some are quite general, some more specific, and some more in-depth. Yet, it is accepted that preventing or curing delusional thinking has not yet acquired a tactical procedure or approach. Ostensibly, this means that the essence of any bona fide delusion is simply not understood by the vast majority of theoretical and/or practicing clinicians. Historically, it means that the trigger, the motive, and the psychic arrangement of forces of the phenomenon defined as delusion have been elusive. Dr. Kellerman, the author of Personality: How it Forms, brings the problem of delusion into sharper focus for a better understanding.

Basics Of Anesthesia 6 E

Author: Ronald D. Miller
Publisher: Elsevier India
ISBN: 8131228983
Size: 65.85 MB
Format: PDF, ePub, Mobi
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With the most authoritative and complete overview of anesthesia theory and practice, the latest edition of Basic Anesthesia, edited by noted anesthesiologist Ronald D. Miller, MD and Manuel C. Pardo, Jr., MD, continues to serve as an excellent primer on the scope and practice of anesthesiology. Widely acknowledged as the foremost introductory text, the new edition-now presented in full color throughout-has been thoroughly updated to reflect new and rapidly changing areas in anesthesia practice including new chapters on awareness under anesthesia, quality and patient safety, orthopedics, and expanded coverage of new ultrasound techniques in regional anesthesiology with detailed illustrated guidance. You can access the full text and image library online at www.expertconsult.com. Obtain a clear overview of everything you need to know about the fundamentals of anesthesia, including basic science and emerging clinical topics. Efficiently retain and synthesize information more easily thanks to a concise, at-a-glance format with numerous illustrations and tables throughout the book that condense complex concepts, and 'Questions of the Day' to assist you in understanding key material presented in each chapter.

The Circuitry Of The Human Spinal Cord

Author: Emmanuel Pierrot-Deseilligny
Publisher: Cambridge University Press
ISBN: 0521192587
Size: 17.16 MB
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A comprehensive review of the corticospinal and spinal contributions to the control of movement in human subjects.

The Autisms

Author: Mary Coleman
Publisher: OUP USA
ISBN: 0199732124
Size: 50.85 MB
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Rev. ed. of: Biology of the autistic syndromes / Christopher Gillberg, Mary Coleman. 3rd ed. 2000.

Fundamental Neuroscience

Author: Larry R. Squire
Publisher: Academic Press
ISBN: 0123858704
Size: 62.54 MB
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Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. A companion web site contains test questions, and an imagebank of the figures for ready use in presentations, slides, and handouts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: * 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness * Companion website with figures, web links to additional material, and test questions * Additional text boxes describing key experiments, disorders, methods, and concepts * Multiple model system coverage beyond rats, mice, and monkeys * Extensively expanded index for easier referencing

Movement Disorders

Author: Mark S. LeDoux
Publisher: Elsevier
ISBN: 0124055168
Size: 60.92 MB
Format: PDF, ePub
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The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. Introduces the scientific foundations for modern movement disorders research Contributing authors are internationally known experts Completely revised with 20% new material Provides a comprehensive discussion of genetics for each type of movement disorder Covers Parkinson's disease, Huntington's disease, dystonia, tremors, and tics