Genomics And Personalized Medicine

Author: Michael Snyder
Publisher: Oxford University Press
ISBN: 0190234768
Size: 67.81 MB
Format: PDF
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In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Law And Economics Of Personalized Medicine

Author: Karin Bosshard
Publisher: Springer
ISBN: 3658220740
Size: 32.29 MB
Format: PDF, Docs
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The book adds to the discussion about strategic approaches towards the translation of personalized medicine into clinical practice. It stresses the importance of non-science related, institutional barriers. A Law and Economics perspective is applied in order to examine the incentives induced by the barriers. An applied part identifies and evaluates policy levers to foster the translation of personalized medicine into Swiss clinical practice.

Personalized Medicine

Author: Gloria Gronowicz
Publisher: CRC Press
ISBN: 1498714927
Size: 16.31 MB
Format: PDF
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Personalized Medicine: Promises and Pitfalls broadly explores the tailoring of medical treatment to a patient’s characteristics, needs, and preferences during all stages of care, including prevention, diagnosis, treatment, and follow-up. The book’s goal is to explain the science behind personalized medicine, what impact it may have on specific diseases, and some of the repercussions of a personalized medical approach on our medical institutions. Novel personalized therapeutic treatments and their scientific basis are discussed by covering topics as diverse as genomics, proteomics, epigenetics, integrative medicine, stem cells, and the factors that influence personal health. A personalized medical system also requires patient involvement in developing a healthy lifestyle, and so this book touches on topics such as the individual’s family history, present and past lifestyle, nutrition, exercise levels, and stress factors. By explaining these broad topics in personalized medicine and the science behind them, we discover how personalized medicine can have a positive impact on an individual’s health.

Infant Gender Selection Personalized Medicine

Author: Anne Hart
Publisher: iUniverse
ISBN: 0595365396
Size: 38.26 MB
Format: PDF
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Personalized medicine is what this book is about-tailoring your lifestyle, food, medicines, treatments, and reproductive choices to your genetic signature. According to Dr. Andrew Y. Silverman, MD, PhD, "The desire to influence the sex of the next child is probably as old as recorded history." "Gender selection is possible because of the way in which sex is determined by our chromosomes. Dr. Ericsson devised patented methods by which X and Y sperm can be separated through filtering processes. Sperm are "layered" over a column of human serum albumin, and they swim down the gradient where they are collected in the bottom layer. "The fraction of sperm that contains the male (Y) bearing sperm is used for insemination if a boy is desired. It is effective 70-75% of the time. "The fraction of sperm that contains the female (X) bearing sperm is used for insemination if a girl is desired. It is effective 70-72% of the time." Use personalized medicine more effectively. Empower consumers by interpreting DNA testing and learning more about infant gender choice by genetics.

Me Medicine Vs We Medicine

Author: Donna Dickenson
Publisher: Columbia University Press
ISBN: 0231534418
Size: 31.81 MB
Format: PDF, ePub
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Personalized healthcare—or what the award-winning author Donna Dickenson calls “Me Medicine”—is radically transforming our longstanding, “one-size-fits-all” model. Technologies such as direct-to-consumer genetic testing, pharmacogenetics in cancer care, private umbilical cord blood banking, and neurocognitive enhancement claim to cater to an individual’s specific biological character. In some cases, these technologies have shown powerful potential, yet in others, they have produced negligible or even negative results. Whatever is behind the rise of Me Medicine, it isn’t just science. So why is Me Medicine rapidly edging out We Medicine, and how has our commitment to collective health suffered as a result? In her balanced, provocative analysis, Dickenson examines the economic and political factors fueling the Me Medicine phenomenon and explores whether it may, over time, damage our individual health as well as our collective well-being. Historically, it is the measures of “We Medicine,” such as vaccination, that have radically extended our life spans, but Dickenson argues that we’ve lost sight of that truth in our enthusiasm for “Me Medicine.” She explores how personalized medicine illustrates capitalism’s flexible talent for creating new products and markets where none existed before—and how this, rather than scientific plausibility, goes a long way toward explaining private umbilical cord blood banking and retail genetics. Drawing on up-to-date scientific evidence, Dickenson critically examines four possible hypotheses driving our Me Medicine moment: a growing sense of threat in our society; a wave of patient narcissism; corporate interests in creating new niche markets; and the dominance of personal choice as a cultural value. She concludes with important and original insights from political theory emphasizing a conception of the commons and the steps we can take to restore its value to modern biotechnology.

Conflict Of Interest And Medical Innovation

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309301718
Size: 12.83 MB
Format: PDF, Mobi
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Scientific advances such as the sequencing of the human genome have created great promise for improving human health by providing a greater understanding of disease biology and enabling the development of new drugs, diagnostics, and preventive services. However, the translation of research advances into clinical applications has so far been slower than anticipated. This is due in part to the complexity of the underlying biology as well as the cost and time it takes to develop a product. Pharmaceutical companies are adapting their business models to this new reality for product development by placing increasing emphasis on leveraging alliances, joint development efforts, early-phase research partnerships, and public-private partnerships. These collaborative efforts make it possible to identify new drug targets, enhance the understanding of the underlying basis of disease, discover novel indications for the use of already approved products, and develop biomarkers for disease outcomes or directed drug use. While the potential benefits of collaboration are significant, the fact that the relationships among development partners are often financial means that it is vital to ensure trust by identifying, disclosing, and managing any potential sources of conflict that could create bias in the research being performed together. Conflict of Interest and Medical Innovation is the summary of a workshop convened by the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health in June 2013 to explore the appropriate balance between identifying and managing conflicts of interest and advancing medical innovation. A wide range of stakeholders, including government officials, pharmaceutical company representatives, academic administrators and researchers, health care providers, medical ethicists, patient advocates, and consumers, were invited to present their perspectives and participate in discussions during the workshop. This report focuses on current conflict of interest policies and their effect on medical innovation in an effort to identify best practices and potential solutions for facilitating innovation while still ensuring scientific integrity and public trust.

Rare Diseases New Insights For The Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 146491852X
Size: 56.34 MB
Format: PDF, ePub
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Rare Diseases: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Rare Diseases in a compact format. The editors have built Rare Diseases: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rare Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Rare Diseases: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Molecular Diagnostics In Dermatology And Dermatopathology

Author: Michael J. Murphy
Publisher: Springer Science & Business Media
ISBN: 9781607611714
Size: 46.42 MB
Format: PDF, ePub, Docs
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Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with ‘traditional’ histologic approaches, and discussions of regulatory, ethical, legal, economic issues and ‘newer’ technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.