Forensic Toxicology

Author: Robert H. Powers
Publisher: CRC Press
ISBN: 1466581956
Size: 36.68 MB
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Designed for upper-level undergraduate and graduate-level courses, Forensic Toxicology: Mechanisms and Pathology introduces toxicology concepts from a forensic perspective. The book provides an understanding of the mechanistic basis of the action of drugs and toxins, addressing their physiologic and pathologic consequences on the affected organ system. It is this essential connection of toxicology to physiology and biological systems that provides the basis for the toxicologist to understand the basis of behavioral effects of drugs, and for the forensic pathologist to determine cause of death when drugs may be involved. The book gives an overview of organ system physiology and pathology, and the ways in which toxins and drugs affect those systems. Case histories, photographs of gross pathology, and photomicrographs further illustrate the processes and effects of toxic substances on the body. The book also focuses on technological advances in the field and includes cases that demonstrate real-world consequences of the effects of toxins upon organ systems, such as impairment in a DUI case or the fatal induction of cardiac arrhythmia. A comprehensive introduction to pathology and toxicologic concepts, Forensic Toxicology: Mechanisms and Pathology describes the means for identifying types of toxins as well as the key patterns and impacts of drug and toxin processes within the body.

Forensic Pathology Of Fractures And Mechanisms Of Injury

Author: Michael P. Burke
Publisher: CRC Press
ISBN: 1439881499
Size: 61.12 MB
Format: PDF
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Practitioners of forensic medicine have various tools at their disposal to determine cause of death, and today’s computed tomography (CT) can provide valuable clues if images are interpreted properly. Forensic Pathology of Fractures and Mechanisms of Injury: Postmortem CT Scanning is a guide for the forensic pathologist who wants to use CT imaging to assist in determining the mechanism of injury that might have contributed to death. Advice from a forensic pathologist using CT images in daily practice Drawn from the author’s work at the Victorian Institute of Forensic Medicine, the book presents an overview of his experience with CT in routine casework, provides an appraisal of the literature with respect to fractures, and offers suggestions for the evaluation of CT images by pathologists. He then suggests what reasonable conclusions can be drawn from the images, the circumstances surrounding the death, and an external examination of the deceased. Includes images and case studies Enhanced with hundreds of CT images that clarify the text and case studies to put the material in context, the book begins by discussing classification of injuries and different types of fractures. It then explores the basics of CT. Next, the book gives a head-to-toe catalogue of various injuries and how they are represented on a CT scan. Finally, the book explores the use of CT in difficult forensic cases such as decomposed and burnt remains, falls, child abuse, and transportation incidents. While not intended to make a forensic pathologist an expert at CT image interpretation, the book enables these professionals to become familiar with the technology so they can competently use it in their practice, heightening the accuracy of their cause of death determinations.

Fundamentals Of Toxicologic Pathology

Author: Wanda M. Haschek
Publisher: Academic Press
ISBN: 0128098422
Size: 56.82 MB
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Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others. Presents revised and updated information for each chapter on systems Contains expanded sections on applied toxicologic pathology Includes the essential information necessary to understand toxicologic pathology in an accessible language

Fundamentals Of Analytical Toxicology

Author: Robert J. Flanagan
Publisher: John Wiley & Sons
ISBN: 0470516283
Size: 27.67 MB
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The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology

Clinical Toxicology

Author: Frank A. Barile
Publisher: CRC Press
ISBN: 142009226X
Size: 26.54 MB
Format: PDF
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Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare workers, industrial hygienists, and safety engineers. This all-inclusive source has been updated to include the latest issues and the most current research in clinical toxicology. Key features in Clinical Toxicology: Principles and Mechanisms include: Convenient and organized categorization of compounds into therapeutic and non-therapeutic agents Tables, drawings, and figures that provide readily accessible, precise data Tables for easy usage and cross-reference to names, indications, effects, adverse reactions, and drug interactions for over 70 common herbal products The brand, generic, and street names of therapeutic agents Topics covered in the Second Edition include: Symptoms of diseases and pathology caused by toxins and clinical drugs Biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products The effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons General physiology and pharmacology principles The widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects

Forensic Toxicology

Author: Nicholas T Lappas
Publisher: Academic Press
ISBN: 0128004649
Size: 29.38 MB
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Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Forensic Toxicology also contains appendices covering the principles of pharmacokinetics and pharmacodynamics, immunology and immunological assays, toxicogenomics, and case studies. Significant emphasis on the fundamental principles and concepts of forensic toxicology Provides students with an introduction to the core tenets of the discipline, focusing on the concepts, strategies, and methodologies utilized by professionals in the field Coauthored by a forensic toxicologist with over 40 years of experience as a professor who has taught graduate courses in forensic and analytical toxicology and who has served as a consultant and expert witness in civil and criminal cases The book's companion website, http://textbooks.elsevier.com/web/Manuals.aspx?isbn=9780127999678 features exclusive web-based content

Information Resources In Toxicology

Author: Philip Wexler
Publisher: Academic Press
ISBN: 0127447709
Size: 47.90 MB
Format: PDF, Docs
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Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added. This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. Key Features * Serves as an all-in-one resource for toxicology information * New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports * Updated to include the latest internet and electronic sources, e-mail addresses, etc. * Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Atlas Of Forensic Pathology

Author: Joseph A. Prahlow
Publisher: Springer Science & Business Media
ISBN: 1617790575
Size: 58.69 MB
Format: PDF
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This book is specifically designed for non-pathologists who normally interact with forensic pathologists. It covers topics within forensic pathology, including the forensic autopsy, postmortem changes and time of death and body identification.

Atlas Of Forensic Pathology

Author: B Suresh Kumar Shetty
Publisher: JP Medical Ltd
ISBN: 9350904683
Size: 12.47 MB
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Concise guide to forensic pathology for undergraduates. Covers many causes of death. Highly illustrated with clinical photographs and descriptions.

Toxicologic Pathology

Author: Pritam S. Sahota
Publisher: CRC Press
ISBN: 1439872120
Size: 56.49 MB
Format: PDF
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As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.