Basic Principles Of Drug Discovery And Development

Author: Benjamin Blass
Publisher: Elsevier
ISBN: 012411525X
Size: 40.40 MB
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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

Smith And Williams Introduction To The Principles Of Drug Design And Action Fourth Edition

Author: H. John Smith
Publisher: CRC Press
ISBN: 9780203304150
Size: 18.47 MB
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Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

Pharmacokinetics In Drug Discovery And Development

Author: Ronald D. Schoenwald
Publisher: CRC Press
ISBN: 9781420010084
Size: 30.42 MB
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Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference. After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

Genomics In Drug Discovery And Development

Author: Dimitri Semizarov
Publisher: John Wiley & Sons
ISBN: 0470409762
Size: 39.42 MB
Format: PDF, ePub, Mobi
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Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

General And Molecular Pharmacology

Author: Francesco Clementi
Publisher: John Wiley & Sons
ISBN: 1118768590
Size: 25.74 MB
Format: PDF, ePub
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With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

Principles Of Clinical Pharmacology

Author: Arthur J. Atkinson
Publisher: Academic Press
ISBN: 0123854717
Size: 36.29 MB
Format: PDF, Kindle
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Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. * Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

Chemical Biology

Author: Natanya Civjan
Publisher: John Wiley & Sons
ISBN: 1118434501
Size: 39.85 MB
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An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Science Of Drug Discovery And Development

Author: Robert Campbell
Publisher: Wiley-Blackwell
ISBN: 9781405157568
Size: 17.82 MB
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Drug discovery and development is an expensive multi-disciplinary effort dependent on chemistry, structural biology, molecular and cell biology, pharmacology, physiology, statistics, computer sciences, engineering, medicine, law and business. It is a major challenge to incorporate all these fields into a single course, however it is also an opportunity to provide advanced students with a unifying context in which to apply knowledge from foundation courses. Rather than simply describing the drug discovery process, an essential goal of this text is to introduce the key decisions that are involved, the types of information needed to make these decisions, and the types of experiments used to obtain that information. In my teaching I have found that focusing on core concepts makes the subject accessible to a wider range of students and facilitates the integration of the knowledge into a context that is accessible and meaningful. This approach also serves to reinforce basic skills of research design and interpretation, and of data-driven decision-making – skills relevant for a large number of potential learning and career directions. This book is intended to provide students with an understanding of the primary steps in the drug discovery and development process, key information needs associated with the decisions that govern the progression of projects from lab to clinic to market, and major research approaches used to provide information, support decision-making, and identify/prioritize candidate drug targets and candidate molecules. Along with a focus on the decision-making process, the text will emphasize the fundamental principles of science. Textboxes will highlight core concepts, techniques, and historic case examples, including examples from global infectious diseases such as malaria and sleeping sickness. End-of-chapter questions, a glossary and a math appendix will ensure that the text is accessible to upper-level undergraduates and graduate students.

Applications Of Pharmacokinetic Principles In Drug Development

Author: Rajesh Krishna
Publisher: Springer Science & Business Media
ISBN: 9780306477669
Size: 10.47 MB
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This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes application of pharmacokinetic principles in new drug development.

Flow Cytometry In Drug Discovery And Development

Author: Virginia Litwin
Publisher: John Wiley & Sons
ISBN: 0470922788
Size: 33.98 MB
Format: PDF, Kindle
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This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.