Basic Pharmacokinetics And Pharmacodynamics

Author: Sara E. Rosenbaum
Publisher: John Wiley & Sons
ISBN: 1119143160
Size: 67.25 MB
Format: PDF, ePub
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Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Haschek And Rousseaux S Handbook Of Toxicologic Pathology

Author: Wanda M. Haschek
Publisher: Academic Press
ISBN: 0124157653
Size: 11.76 MB
Format: PDF, Docs
View: 2346
Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Pharmacology And Physiology For Anesthesia E Book

Author: Hugh C. Hemmings
Publisher: Elsevier Health Sciences
ISBN: 1455737933
Size: 60.39 MB
Format: PDF, ePub
View: 1048
Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Pharmacology and Physiology for Anesthesia. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.

Farmacolog A Humana

Author: Jesús Flórez Beledo
Publisher: Elsevier España
ISBN: 8445825232
Size: 34.82 MB
Format: PDF, Kindle
View: 2031
* Nueva edición del texto "clásico" de la farmacología española en el ámbito del Grado de Medicina y de Farmacia. Bajo la dirección del Profesor Jésus Flórez y la presencia de los Dres Armijo y Mediavilla como directores asociados, se ha contado en esta ocasión, con la presencia de nuevos colaboradores, que aseguran renovación y continuidad. * La filosofía de la obra es seguir con la misma tradición expositiva que en las pasadas ediciones, lo que la ha convertido en la obra de mayor prestigio y con la que muchas generaciones de médicos han aprendido la Farmacología. Su profundidad expositiva se acompaña de una gran precisión a la hora de definir los diferentes conceptos. * A través de sus diferentes ediciones, el objetivo fundamental de la obra es explicar el cómo, el por qué y de qué modo los fármacos son instrumentos indispensables en el manejo de la enfermedad. Y, al mismo tiempo, señalar las condiciones que se deben cumplir para que este manejo sea realizado de forma acertada, fiable y segura en funciones de las necesidades individuales de un paciente concreto. * Los diferentes autores han hecho un importante esfuerzo para reforzar aquellos conceptos que se consideran esenciales para la farmacología moderna: el extenso mundo de los ac monoclonales, la terapia individualizada frente a diversas patologías (incluido el cáncer), la reacción inmunitaria forma que el extenso índice de contenidos refleja las últimas novedades y tendencias en la disciplina.

The Comprehensive Textbook Of Healthcare Simulation

Author: Adam I. Levine
Publisher: Springer Science & Business Media
ISBN: 1461459931
Size: 67.18 MB
Format: PDF, Docs
View: 501
The Comprehensive Textbook of Healthcare Simulation is a cohesive, single-source reference on all aspects of simulation in medical education and evaluation. It covers the use of simulation in training in each specialty and is aimed at healthcare educators and administrators who are developing their own simulation centers or programs and professional organizations looking to incorporate the technology into their credentialing process. For those already involved in simulation, the book will serve as a state-of-the-art reference that helps them increase their knowledge base, expand their simulation program’s capabilities, and attract new, additional target learners. Features: • Written and edited by pioneers and experts in healthcare simulation • Personal memoirs from simulation pioneers • Each medical specialty covered • Guidance on teaching in the simulated environment • Up-to-date information on current techniques and technologies • Tips from “insiders” on funding, development, accreditation, and marketing of simulation centers • Floor plans of simulation centers from across the United States • Comprehensive glossary of terminology

Mouse Models Of Human Cancer

Author: Eric C. Holland
Publisher: Wiley-Liss
ISBN: 9780471444602
Size: 49.84 MB
Format: PDF, Mobi
View: 2842
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

The Emerging Discipline Of Quantitative Systems Pharmacology

Author: Tarek A. Leil
ISBN: 2889196429
Size: 69.45 MB
Format: PDF, Mobi
View: 1434
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.


Size: 72.29 MB
Format: PDF, Docs
View: 4319

Aerospace Medicine And Biology

Size: 17.72 MB
Format: PDF
View: 4583
A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).