Advances In Biological Solid State Nmr

Author: Frances Separovic
Publisher: Royal Society of Chemistry
ISBN: 1849739102
Size: 21.56 MB
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Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions.

Perspectives On Solid State Nmr In Biology

Author: S.R. Kiihne
Publisher: Springer Science & Business Media
ISBN: 9401725799
Size: 12.25 MB
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Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solution methods or diffraction techniques. This proceedings -; from a recent international workshop - captures an image of the latest developments and future directions for solid state NMR in biological research, particularly on membrane proteins. Detailed information on how hormones or drugs bind to their membrane receptor targets is needed, e.g. for rational drug design. Higher fields are bringing clear improvements, and the power of solid state NMR techniques for studying amorphous and membrane associated peptides, proteins and complexes is shown by examples of applications at ultra-high fields. Progress in protein expression, experimental design and data analysis are also presented by leaders in these research areas.

Annual Reports On Nmr Spectroscopy

Author:
Publisher: Academic Press
ISBN: 0128022027
Size: 31.52 MB
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Annual Reports on NMR Spectroscopy provides a thorough and in-depth accounting of progress in nuclear magnetic resonance (NMR) spectroscopy and its many applications. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained as much significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. Serves as the premier resource for learning the new techniques and applications of NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules

Solid State Nmr Studies Of Biopolymers

Author: Anne E. McDermott
Publisher: John Wiley & Sons
ISBN: 1118588886
Size: 15.12 MB
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The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) - the ultimate online resource for NMR and MRI. The field of solid state NMR of biological samples [ssNMR] has blossomed in the past 5-10 years, and a cohesive overview of the technology is needed for new practitioners in industry and academia. This title provides an overview of Solid State NMR methods for studying structure dynamics and ligand-binding in biopolymers, and offers an overview of RF pulse sequences for various applications, including not only a systematic catalog but also a discussion of theoretical tools for analysis of pulse sequences. Practical examples of biochemical applications are included, along with a detailed discussion of the many aspects of sample preparation and handling that make spectroscopy on solid proteins successful. About EMR Handbooks / eMagRes Handbooks The Encyclopedia of Magnetic Resonance (up to 2012) and eMagRes (from 2013 onward) publish a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of EMR Handbooks / eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of articles from eMagRes. In consultation with the eMagRes Editorial Board, the EMR Handbooks / eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written (together with updates of some already existing articles) to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes View other eMagRes publications here

Proteins Advances In Research And Application 2012 Edition

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Publisher: ScholarlyEditions
ISBN: 1464990530
Size: 29.70 MB
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Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Proteins. The editors have built Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances In Oxygen 17 Nmr For Biological Structure Determination

Author: Eric George Keeler
Publisher:
ISBN:
Size: 17.83 MB
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The determination of the structures of biological systems, such as, fibril-forming peptides and proteins, membrane proteins, and viruses, by solid-state nuclear magnetic resonance (NMR) spectroscopy has materialized as an important field due to the high-resolution details that the technique provides. While solid-state NMR studies have focused on the three prevalent spin I = 1/2 nuclei present in biomolecules, oxygen has largely been ignored as a probe of the structure of such systems. Described in this thesis are the results of studies to advance the use of solid-state 17O NMR spectroscopy for structure determination of biological molecules by utilizing the sensitivity of the electric field gradient (EFG) and chemical shift tensors of 17O. We demonstrated a distinct chemical shift range for bound water in crystalline amino acids and dipeptides and identified discordance between experimental and calculated EFG parameters. This difference was further studied via variable temperature 17O NMR experiments on barium chlorate monohydrate that demonstrated the effect of the librational motions of the bound water on the NMR measurable 17O quadrupolar coupling constant. A well resolved splitting in the 17O magic-angle spinning NMR spectrum was shown at the'rigid lattice limit of the bound water that was determined to be caused by the interaction between the 1H-1H dipole coupling and the 1H-17O dipole couplings. Further study of bound water environments is presented exhibiting the ability to resolve multiple unique bound water environments in a single system by high-resolution 17O NMR spectroscopy. We demonstrate the ability to utilize dynamic nuclear polarization (DNP) NMR to polarize multiple nuclei via an endogenous radical dopant that does not disrupt the native crystal structure. Efficient 17O labeling of a dipeptide is explored to enable the study of the dipeptide via 17O NMR. Utilizing one- and two-dimensional double resonance correlation spectroscopy, the interatomic correlations between oxygen and carbon, nitrogen, and hydrogen atoms were explored, exhibiting the ability of 17O NMR to determine structural characteristics of biomolecular solids. A study on the use of DNP NMR to study biosilica entrapped proteins is also presented as part of this thesis.

Nmr In Biological Systems

Author: K.V.R. Chary
Publisher: Springer Science & Business Media
ISBN: 1402066805
Size: 66.22 MB
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During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.

Annual Reports On Nmr Spectroscopy

Author: Graham A. Webb
Publisher: Elsevier
ISBN: 9780125054553
Size: 34.99 MB
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Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science where precise structural determination is required and where the nature of interactions and reactions in solution is being studied. Annual Reports on NMR has established itself as a premier means for the specialist and nonspecialist alike to become familiar with new techniques and applications of NMR spectroscopy. * Includes comprehensive review articles on NMR Spectroscopy * NMR is used in all branches of science * No other technique has grown to such importance as NMR Spectroscopy in recent years

Nuclear Magnetic Resonance Of Biological Macromolecules

Author:
Publisher: Elsevier
ISBN: 0080496881
Size: 50.52 MB
Format: PDF
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This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

Nuclear Magnetic Resonance

Author: G. A. Webb
Publisher: Royal Society of Chemistry
ISBN: 0854043527
Size: 56.85 MB
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For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.